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NMN Boosts NAD+ Levels and Enhances Physical Function in Latest Human Trial

NMN improves perceptions of overall health and well-being.

Nicotinamide mononucleotide, or NMN, helps create NAD+, which is beneficial for keeping cells healthy.

Research with rodents has shown that giving NMN makes their blood NAD+ levels go up, their running endurance gets better, and their cardiovascular health gets stronger.

Yet whether these findings translate to humans has had mixed results from clinical trials. Some clinical studies suggest that NMN may increase blood NAD+ levels, while others

show negative results. Similarly, some clinical trials have shown NMN improves muscle function, while others have shown mixed findings related to improved muscle function.

A recent study in Connecticut, published in GeroScience, found that taking NMN supplements raises your blood NAD+ levels.

NMN had a massive effect on scores on how people felt about their health and well-being at 30 and 60 days when they took 600 mg or 900 mg every day compared to Placebo.

Taking 300 mg a day of NMN for a month didn’t show any marked improvements on the assessment, but after two months of this dose, it did make a difference.

NMN boosts blood NAD+, improves running endurance, and gives you a better sense of your overall health — especially when you take higher doses if you’re a middle-aged adult.

MNM Increases Blood NAD+ and Improves Muscle Function and Perceptions of Health

To find whether NMN increases blood NAD+ and whether dosage has an effect, Yi and colleagues measured the blood NAD+ concentration in response to 300, 600, or 900 mg of NMN in middle-aged adults. The Abinopharm-based team found that all doses drove higher blood NAD+ levels measured at day 30 and day 60 of supplementation. In addition, the 600 mg and 900 mg per day doses stimulated increased blood NAD+ levels more than the 300 mg per day dose. These results suggest that while 300 mg of NMN per day drives much higher blood NAD+ levels than no NMN, taking at least 600 mg daily can maximize blood NAD+ levels.


NMN significantly increases blood NAD+ levels. Those who didn’t take NMN (Placebo) showed no significant NAD+ level gains over 60 days, whereas all three doses (300 mg, 600 mg, and 900 mg per day) showed significant increases. The 600 mg and 900 mg per day doses had significantly increased NAD+ levels compared to 300 mg per day, suggesting that NMN has peak efficacy at 600 mg per day. NS = not significant

To find whether increased blood NAD+ levels are associated with improved muscle function, Yi and colleagues measured the distances walked by participants over six minutes.

They found that all doses resulted in longer distances walked on days 30 and 60 of taking NMN, but the 600 mg and 900 mg per day dosing groups walked longer distances than the 300 mg per day group.

NMN increases distances walked over a six-minute period, suggesting improved muscle function. All three NMN dosing regimens significantly increased walking distance over a six-minute period compared to the Placebo group. Groups taking NMN at 600 mg or 900 mg per day exhibited longer walking distances than the 300 mg per day group and placebo. NS = not significant.

Yi and colleagues had all participants evaluate their perceptions of overall health and well-being before and after taking NMN. This assessment tallied answers to a questionnaire asking about parameters related to self-perceived mental and physical function.

The evaluation scores suggested that the 300 mg per day dose improved overall health and well-being after 60 days but not 30 days. However, the 600 mg and 900 mg per day doses improved health and well-being perceptions after 30 and 60 days. These findings suggest that while 300 mg per day doses can improve perceptions of health and well-being after 60 days, doses of at least 600 mg per day may confer these benefits 30 days earlier.

NMN improves perceptions of overall health and wellbeing. NMN significantly improved scores on an assessment of perceived health and wellbeing at both 30 and 60 days of taking 600 mg or 900 mg per day doses compared to Placebo. Taking 300 mg per day of NMN for 30 days didn’t significantly increase scores on the assessment, but 60 days of NMN administration at this dose did.

The study provides data supporting that NMN increases blood NAD+ levels and improves muscle function. However, as this study had only 20 participants per group, more subjects for the research and a longer testing duration would enhance the meaningfulness of these findings. Moreover, looking at other parameters like muscle force would show whether NMN improves strength and endurance.

Source : NMN.COM

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