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What is the Best NMN Delivery System?

Individuals who are familiar with NMN supplements and those interested in using the supplement would normally want the most effective way to get the supplement into the body. This would mean the delivery system that can get the highest fraction of the compound into the bloodstream in its active form (best bioavailability). The higher the fraction gotten into the bloodstream, the more effective the compound is.

While there are different delivery systems used in NMN packaging, the effectiveness of most is not backed by scientific research. The only forms that have been exposed to research are the capsule and powder delivery systems. However, this article will explore all marketed NMN delivery systems and the various features they offer in terms of bioavailability.

Key Takeaways:

  • Various NMN supplement delivery systems, including capsules, powders, sprays, suppositories, and topical products, are available.
  • Choosing the best delivery system depends on personal preference, dosage control, potential side effects, and individual health conditions.
  • Research has shown that capsules have a good bioavailability profile, and the powder form has also shown a promising bioavailability profile.

NMN Capsules

NMN capsules are the preferred choice for many individuals seeking to supplement with NMN. Apart from their popularity among users, studies have also shown that 600mg of encapsulated NMN significantly raised NAD+ levels in the blood, while the activity increase is not significant at higher NMN amounts. Another form of capsules that can be used in NMN delivery is enteric capsules, which are created to withstand the stomach’s acidic environment. This capsule, in theory, can protect its NMN contents and get it to the small intestine, where it would be absorbed. However, this theory has not been extensively tested.

Some of the advantages offered by the NMN capsule delivery system include:

  • Controlled Release and Bioavailability: Enteric capsules are designed to withstand stomach acidity, releasing their contents in the intestines for better absorption.
  • Dosage Precision: Capsules allow precise control over the dosage of NMN, which is essential for consistent supplementation.

NMN Powder

NMN Powder

NMN powder is an excellent NMN supplement delivery system for those looking for a versatile and customizable option. The powdered form of NMN can be mixed into liquids such as water, juice, or added to foods such as yogurt or smoothies. NMN powder is unique because it gives users precise control over their dosage, allowing for tailored supplementation according to individual needs. Additionally, it does not contain any other substances or fillers that are normally used to make capsules.

 Unlike pre-measured capsules or sprays, NMN powder allows for more flexible dosing, with users able to gradually increase or decrease their intake as desired.

Also, studies carried out on mice show that when NMN is dissolved into the drinking water of these rodents, their blood NAD+ levels are significantly raised. Also, other studies have shown that NMN is degraded in the stomach acid, hence showing that there might not be a need for the use of enteric capsules. However, no studies have compared the bioavailability between the capsule and powder forms.

Sublingual NMN Powder

For those seeking a fast-acting and potentially more bioavailable delivery method, sublingual NMN powder is worth considering. Sublingual NMN involves placing the supplement under the tongue, where it can be absorbed directly into the bloodstream. This way, the various effects of the GIT are bypassed, and the permeable structures under the tongue make it faster to get the powder into the bloodstream. Also, the sublingual powder forms allow it to be better absorbed than the capsule forms which contains various additives and binders that can interfere with the process. The powder, on the other hand, is pure and doesn’t contain any additives ot sweeteners.

Liposomal NMN 

Liposomal NMN is a form of Nicotinamide Mononucleotide encapsulated within liposomes, small spherical structures composed of natural phospholipids, akin to cell membranes. This encapsulation is designed to enhance the delivery and absorption of NMN into the body. The liposomal form of NMN is thought to offer improved bioavailability because the liposomes protect the NMN from degradation in the digestive system, ensuring more of the compound reaches the bloodstream intact.

The absorption characteristic of liposomal NMN is primarily attributed to the liposomes’ ability to fuse with cell membranes, facilitating direct entry of NMN into the cells. This method bypasses the usual pathways of absorption and degradation, potentially leading to increased cellular uptake and efficacy. Furthermore, the liposomal delivery system may allow for a more sustained release of NMN, maintaining stable levels in the bloodstream and offering prolonged benefits. However, it’s important to note that while the theoretical advantages of liposomal NMN are compelling, more empirical research is needed to fully validate these benefits.

Nasal Spray

Nasal sprays offer an alternative option for NMN delivery through the mucous membranes in the nose. By bypassing the GI tract, nasal sprays allow NMN to be directly absorbed, potentially enhancing bioavailability and efficacy. This non-oral delivery system provides a discreet and convenient option for those who prefer not to swallow capsules or powders or experience difficulty swallowing. Also, it helps the supplement bypass the Blood-Brain Barrier (BBB), giving easier access to the brain. However, studies have shown that the supplement crosses the blood-brain barrier when administered through other methods, so the nasal sprays might not be necessary.

Additionally, nasal sprays may have some drawbacks, such as discomfort, burning sensation, or irritation in the nasal cavity.

Topical NMN for Skin

Topical NMN is an innovative method for enhancing the health and appearance of the skin. NMN creams or serums can be applied directly to the skin, where they are readily absorbed to produce a range of benefits.

Research suggests that topical NMN can promote skin rejuvenation and reduce the visible signs of aging. One study found that topical NMN application improved skin texture, hydration, and elasticity in aging mice. The same study also showed that NMN could repair damaged DNA in skin cells, potentially slowing down the aging process.

NMN Suppositories

Suppositories are a unique and effective way to deliver NMN directly into the bloodstream, bypassing the digestive system. This method of delivery is especially beneficial for individuals who experience digestive issues and may struggle with oral delivery methods. Additionally, suppositories offer potentially higher bioavailability compared to other delivery methods. Unlike capsules or powders, suppositories enter the bloodstream through the bloodstream of the rectum, allowing for faster and more efficient absorption of NMN. However, regular use of suppositories may be uncomfortable or inconvenient for many individuals.

Considerations for Choosing an NMN Delivery System

Choosing the right NMN supplement delivery system requires careful consideration of several factors. Each delivery system’s unique form affects how well the body absorbs NMN and how quickly it takes effect. Consult with a healthcare professional before starting any NMN supplementation regimen to determine the most suitable delivery system for your specific needs. They can advise on potential interactions with medications, underlying health conditions, and other factors. Below are a few things to consider when selecting an NMN delivery system.

Personal Preference

Personal preference plays a significant role in selecting the best NMN delivery system. Some people prefer to take capsules or powder, while others find sprays or suppositories more convenient. Consider your preferences, and choose a delivery system you will feel comfortable using in the long run.

Ease of Use

The ease of use of an NMN delivery system is another crucial factor. Capsules and powders are relatively simple and convenient to use, requiring only water or other beverages to swallow. In contrast, sprays and sublingual options tend to be more challenging to administer. Consider how easy the delivery method is to incorporate into your daily routine.

Desired Dosage Control

NMN powder is preferred for individuals who want to control their dosage precisely. Powder allows users to adjust the dosage according to individual needs. Capsules and sprays offer pre-measured doses, which may be ideal for those who prefer a convenient option.

Potential Side Effects

There are usually no adverse side effects of using NMN in healthy individuals. However, ingesting high doses of the supplement (up to 6g) led to side effects such as dizziness, vomiting, and headaches. Before starting an NMN supplementation regimen, consult your doctor about potential side effects.

Individual Health Conditions

Individual health conditions must be considered when selecting an NMN delivery system. Suppositories may be the best option for individuals with gastrointestinal issues as they bypass the digestive system. For those sensitive to capsules, powders or sublingual options may be better. Consult with a healthcare professional to determine the most suitable NMN delivery system for your specific needs.

What is the Top NMN Delivery System?

Based on existing scientific evidence, the best NMN delivery system is the encapsulated microcrystalline NMN supplement. However, this isn’t a definite answer as many studies to compare other means of delivery haven’t been done. Also, NMN injectables aren’t yet marketed, even though injectables are known to offer close-to-maximum bioavailability.  However, the problem of invading the skin with needles also exists. Therefore, there is a need for more scientific studies on each dosage form to determine what has the best bioavailability. 

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